The Sea Robbers will take comfort from the fact that they are unbeaten in the league this season, but they face a side that looking to keep their 100 percent winning record.
Gavin Hunt's men are yet to lose to a match thus far having won both their opening matches of the season.
This however, will be their toughest test yet with Pirates very tough to beat when playing in front of their home fans.
Wits have already collected three points against another Soweto giant in Kaizer Chiefs, and the players will be motivated and eager to claim another big scalp in a short period of time.
|Game||Orlando Pirates v Bidvest Wits|
|Date||Wednesday, August 15|
|Time||7:30pm SA Time|
TV Channel, Live Score & How To Watch
|Live Match Centre||TV Channel|
Squads & Team News
|Goalkeeper||Brilliant Khuzwayo (injured)|
|Defender||Mthokozisi Dube (suspended)|
|Midfielders||Thabo Qalinge (injured), Luvuyo Memela|
Sredojevic will have to make a few change or two to the team that lost to Matsatsantsa with Mthokozisi Dube suspended after receiving his marching orders in the MTN8.
Ntsikelelo Nyauza, Abbubakar Mobara and Thabo Matlaba are alll available to play on the right hand side of the Bucs defence, while the coach could also opt to play Marshall Munetsi at centre-back and shift Happy Jele to the right.
Ben Motshwari impressed on his debut for Pirates, while Mpho Makola also did well alongside Xola Mlambo in midfield.
With Thabo Qalinge and Luvuyo Memela out injured, either Vincent Pule or Kudakwashe Mahachi will be deployed on the flanks, but it is upfront where real changes are needed.
Thamsanqa Gabuza showed glimpses of an improved player against SuperSport, and perhaps he may be given a chance to shine against Hunt's charges.
Potential Pirates XI: Mpontshane; Nyauza, Jele, Shitolo, Maela; Nyatama, Mlambo, Pule; Lorch, Shonga, Mulenga.
Meanwhile, the Students have given little away in terms of who's available and not for this encounter.
This means Pirates can plan their game around the same players that ran riot against Chiefs last week.
Hunt appears to have found a recipe for success this season, and chances are that he won't fix what's not broken.
Potential Wits XI: Keet, Johannes, Hlatshwayo, Mkhwanazi, Hlanti, Monare, Hotto, Alexander, Dzvukamanja, Motupa, Macuphu.
The last time these two sides met, Pirates thumped Wits 4-0 in a match which was played behind closed doors at the same venue.
It also marked Bucs' first win over the Students in six consecutive league matches.
In head-to-head stats, Pirates and Wits have met 20 times in the league since 2008, with both sides winning seven each while there have been six draws between them.
Pirates have found the back of the net 19 times against Wits, while conceding 16 in the process.
Augustine Mulenga and Xola Mlambo have been head and shoulders above the rest, but there's also Vincent Pule, who will get a chance to face Wits for the first time since leaving them at the end of last season.
Wits have Gift Motupa, who will also make his return to the Orlando Stadium after being deemed surplus to requirements by Sredojevic.
Deon Hotto has been superb for the Clever Boys having found the back of the twice already since his move to the Braamfontein-based outfit.