The mercurial Argentine has netted at a remarkable rate down the years, with his efforts helping him to five Ballon d’Or awards and countless records.
He has, however, faced something of a Chelsea hoodoo over the course of his continental endeavours.
Messi has faced the Blues on eight previous occasions, but has never troubled the scorers to post the longest drought of a goal-laden spell at Camp Nou.
Messi first faced Chelsea back in 2006, as Barcelona secured a 3-1 aggregate victory over the Blues in the last-16.
The two sides then met again in the group stage the following season, with Barca suffering a 1-0 defeat at Stamford Bridge and being held to a 2-2 draw on home soil.
Chelsea then suffered an agonising away goals defeat in the semi-finals of the 2008-09 competition, with Andres Iniesta firing home a last-gasp effort in west London.
Messi’s best opportunity to net against the Blues then presented itself during another semi-final showdown in 2012, but he crashed a penalty against the crossbar as Chelsea progressed 3-2 on aggregate.
He will need no reminding of that night when the two teams meet again, with that contest representing the only blot on Barca’s knockout copybook against Premier League foes.
6 - Barcelona have progressed from six of their last seven Champions League knockout ties against English opposition - the exception was against Chelsea in the semi-final in 2011/12. History. #UCLDraw— OptaJoe (@OptaJoe) December 11, 2017
In this season’s last 16, Chelsea will welcome Barca to England for the first leg of their continental showdown before heading to Catalunya for the return date.