The £75 million centre-back is the only change to the starting line-up that ousted Manchester City 4-3 last time out; an encounter he missed through a tight hamstring.
The world’s most expensive defender replaces Dejan Lovren alongside Joel Matip, with the Croatian absent through illness.
Mohamed Salah has recovered from a virus to line up in attack while Ragnar Klavan has shaken off a similar issue to make the bench.
Juventus-target Emre Can assumes the captaincy as the longest-serving member of the XI.
There is no place in the matchday squad for Daniel Sturridge, who is fit but could depart the club this month with Inter Milan submitting a loan offer for his services.
Jordan Henderson (hamstring) and Alberto Moreno (ankle) are both in full training, but will not be rushed back into the fold.
Liverpool XI: Karius, Gomez, Matip, Van Dijk, Robertson, Can, Wijnaldum, Oxlade-Chamberlain, Salah, Mane, Firmino
Liverpool subs: Mignolet, Klavan, Alexander-Arnold, Milner, Lallana, Ings, Solanke