The Reds bowed out of the FA Cup at the fourth-round stage to Championship opposition, with Anfield proving to be something of an unhappy hunting ground for Klopp's charges of late.
The Swans secured a thrilling 3-2 victory in the Premier League, while the Saints dumped Liverpool out of the EFL Cup in a two-legged semi-final.
Wolves have now compounded Klopp’s misery, with the German coach enduring his toughest run on home soil in close to a decade.
3 - Jurgen Klopp has suffered three consecutive home defeats as a manager for the first time since April 2007 (with Mainz). Tamed.— OptaJoe (@OptaJoe) January 28, 2017
Breaking their home hoodoo is not about to get any easier for Liverpool either, with Chelsea next up at Anfield on Tuesday.
Liverpool will hope to have recovered by then, but there are issues to address.
The FA Cup has eluded them once again, with another setback suffered against second tier opposition.
3 - Liverpool's last three FA Cup defeats at Anfield have all been to second tier sides (Barnsley 2008, Reading 2010, Wolves 2017). Upset.— OptaJoe (@OptaJoe) January 28, 2017
It is back to the drawing board for Klopp and his squad, with attention now narrowed on a fading Premier League title challenge.