According to the club, Khune has a knock above his eye, and it is swollen.
The 30-year-old was rushed to hospital soon after leaving the pitch at the Nelson Mandela Bay Stadium in the closing stages of the game.
Khune has knock above his eye and it is swollen. He has been taken to hospital for a scan to determine the extent of his injury #KCOneTeam— Kaizer Chiefs (@KaizerChiefs) November 5, 2017
Khune's injury comes at a time when the South African national team, Bafana Bafana, need him the most.
Stuart Baxter's will be monitoring Khune's situation with keen interest, as he begins to prepare for back-to-back matches against Senegal in the 2018 Fifa World Cup qualifying campaign.
Chiefs will hope to have their number one goalkeeper back before their Telkom Knockout Cup semi-final clash against Bidvest Wits on the weekend of November 18 and 19.