Bayern have never lost a competitive match against a Turkish side in European competition, but their veteran head coach warned that maintaining that record will be no easy task.
"They are a very good team," he said. "We need to bring our best performances to both games in order to progress."
Since Heynckes returned for a fourth spell in charge of Bayern in September they have only lost once in all competitions, a run that has seen them return to the top of the table and progress in Europe.
And that upturn in form is something sporting director Hasan Salihamidzic believes gives them the edge against Besiktas.
"We know how strong Besiktas are," he told FCB.tv.
"We [have] followed their progress because they were in Leipzig's group. It's a difficult draw. We'll see what happens.
"There'll definitely be an exceptional atmosphere over there, but there will be here in Munich as well.
"We're looking forward to it. Obviously it's a disadvantage to play at home first, but we're good enough and accept it."