The hosts have everything to play for at the Jawaharlal Nehru Stadium in New Delhi. Having lost their first two games, nothing short of a win will keep them in the competition beyond the group stage.
A 2-1 loss to Colombia followed a 3-0 reversal to the USA in their opener.
“We have the utmost respect for our opponents [Ghana] but we will give them a very tough fight, even tougher than we gave Colombia," captain Amarjit Singh said.
"It is a matter of survival and we will do anything to go into the next round."
It was joy for the Colts as Jeakson Singh Thounaojam scored India's first ever goal at a Fifa tournament in their second game.
But having failed to hold on for a draw as Colombia fetched the winner seven minutes to full-time, the hosts are looking to go beyond just scoring against the Black Starlets.
“Against Ghana, we will need a lot of support," goalkeeper Dheeraj Singh added.
"We will give it our very best on the pitch.
"I expect all to be cheering for us like they have done for us.
"We won’t disappoint them. Come and back the blue."
India are currently bottom of Group A.