Barcelona have already wrapped up the Liga title and come into the clash 15 points better off than bitter rivals Real, though the fixture will allow the numerous sub-plots to unfold once again.
Lionel Messi vs Cristiano Ronaldo, La Masia vs the Galacticos, Catalunya vs Spain.
Which of the two sides comes out on top means little to anyone other than the supporters, such has been Barca's dominance this term, but the world will still stand still as the two giants of Spanish football swing it out this weekend.
Ahead of the game, Goal has put together a Clasico quiz.
Test yourself and let us know how you get on in the comments!