The Catalan side have an 11-point lead at the top of the table and need just a draw to seal the championship, but a win would help consign hosts Deportivo to the Segunda Division.
However, Ernesto Valverde's men may not be in for an easy stroll over the finish line, as their away form has held them back in recent weeks, having drawn four of their last six on the road in the league.
|Game||Deportivo vs Barcelona|
|Date||Sunday, April 29|
|Time||19:45 BST / 14:45 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How to Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV, as well as on a web browser.
|US TV channel||Online stream|
|beIN Sports||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Football and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Football||Sky Go|
Squads & Team News
|Goalkeepers||Koval, Ruben, Tyton|
|Defenders||Sidnei, Juanfran, Navarro, Schar, Luisinho, Valentin, Boveda, Albentosa,|
|Midfielders||Guilherme, Borges, Mosquera, Krohn-Dehli, Muntari, Colak, Bakkali, Valle, Cartabia, Gil,|
|Forwards||Perez, Adrian, Adone|
Federico Cartabia, Eneko Boveda and Sulley Muntari are all still out of action for the home side.
Potential Sevilla starting XI: Ruben, Juanfran, Schar, Albentosa, Luisinho, Mosquera, Guilherme, Borges, Colak, Perez, Lopez.
|Goalkeepers||Ter Stegen, Cillessen|
|Defenders||Semedo, Pique, Alba, Digne, Umtiti, Mina, Vermaelen|
|Midfielders||Mosquera, Colak, Gil, Exposito, Borges, Guilherme, Bakkali, Valle|
|Forwards||L. Suarez, Messi, Dembele, Alcacer|
Barca will be without the suspended Sergi Roberto, but have no fresh injury worries ahead of the game.
Potential Barcelona starting XI: Ter Stegen, Semedo, Pique, Umtiti, Alba, Busquets, Paulinho, Iniesta, Coutinho, Suarez, Messi.
Betting & Match Odds
Barcelona are considered to be favourites with dabblebet, who offer odds of 2/7 on them, while Deportivo are priced at 17/2. A draw is available at 5/1.
Barca need just a point to wrap up the title race with four games to go and ensure Ernesto Valverde's first season in charge ends with a double of trophies.
The Catalan side have been the dominant force in the Spanish top flight all season, but their recent inconsistency on the road and Deportivo's sudden rejuvenation may mean a difficult night awaits them.
Deportivo sit third from bottom in the table and look doomed to go down, but they did win this fixture 2-1 last term and replicating that achievement could set them up for a strong finish.
Lionel Messi will be gunning for goals, though, as he hopes to pull even further away from Cristiano Ronaldo at the top of the league' scoring charts and challenge Liverpool hero Mohamed Salah for the Golden Boot.
The Argentine is on 29 goals in 31 games, five ahead of Ronaldo, and has netted 17 times in 16 appearances against Deportivo, but drew a blank on the last two occasions. He will be determined to prevent it from becoming three in a row.