Jose Mourinho's side slipped up two weeks ago against Huddersfield Town, allowing Manchester City to open up a lead at the top of the table, but they have strung together three successive victories since then and appear determined to close the gap.
Chelsea, meanwhile, are even further off the pace, drifting nine points behind the leaders and they are currently navigating through a difficult period under Antonio Conte's stewardship.
|Game||Chelsea vs Manchester United|
|Date||Sunday, November 5|
|Time||16:30 GMT / 11:30 ET|
TV CHANNEL & LIVE STREAM
In the United Kingdom (UK), the match will be available to watch live on television on Sky Sports Premier League and by stream via Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
In the United States (US), the match will be available to watch live on television on NBCSN and by stream via NBC Sports Live.
|US TV channel||Online stream|
|NBCSN||NBC Sports Live|
SQUADS & TEAM NEWS
|Goalkeepers||Caballero, Courtois, Eduardo|
|Defenders||Rudiger, Alonso, Zappacosta, Cahill, Christensen, Azpilicueta, Luiz, Clarke-Salter, Baba, Sterling|
|Midfielders||Kante, Drinkwater, Fabregas, Hazard, Pedro, Bakayoko, Moses, Kenedy, Musonda, Willian, Scott, Ampadu|
There are lingering doubts over the fitness of N'Golo Kante, meaning that Tiemoue Bakayoko is likely to continue alongside Cesc Fabregas in midfield.
Danny Drinkwater is available for selection, but the former Manchester United youth player may have to make do with a place on the bench against his old club.
Potential starting XI: Courtois; Cahill, Azpilicueta, Luiz; Zappacosta, Alonso, Bakayoko, Fabregas, Hazard, Pedro; Morata.
|Position||Manchester United players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Lindelof, Bailly, Jones, Smalling, Valencia, Shaw, Tuanzebe, Rojo, Blind, Darmian|
|Midfielders||Pogba, Mata, Lingard, Carrick, Young, Herrera, Mkhitaryan, Fellaini, Matic, Mitchell, McTominay|
|Forwards||Lukaku, Ibrahimovic, Martial, Rashford|
Manchester United will be without Paul Pogba and Marouane Fellaini, while Zlatan Ibrahimovic and Marcos Rojo are also sidelined.
Phil Jones and Antonio Valencia sat out United's Champions League win over Benfica but they should come back into the team.
Potential starting XI: De Gea; Valencia, Jones, Bailly, Blind; Matic, Herrera, Mkhitaryan, Lingard; Rashford, Lukaku.
BETTING & MATCH ODDS
Chelsea are favourites at 8/5 according to dabblebet, with Manchester United priced at 2/1 to beat the Blues. A draw between the sides at Stamford Bridge is an 21/10 bet.
The ramifications of Sunday's game at Stamford Bridge could potentially be far-reaching, with both sides in the hunt for Premier League glory.
Defeat for Man United can deal a serious dent to their chances of catching Manchester City as it could see an eight-point gap open up between the teams in the lead-up to the busy winter period.
Chelsea, meanwhile, have already lost three games this season and a fourth defeat would be a hammer blow to the reigning champions' hopes of defending their title. Indeed, a home defeat to the Red Devils so soon after their embarrassing Champions League capitulation against Roma would heap more pressure on Conte.
With the stakes so high for both sides, Sunday's encounter is sure to have plenty of intensity and, with the narrative of former heroes such as Juan Mata, Nemanja Matic and Mourinho returning to Stamford Bridge, there will be no shortage of incident.