Just one point separates the two London rivals in the league as they sit third and fourth respectively, with both aiming to keep pace with leaders Manchester City - themselves four points clear of Chelsea.Maurizio Sarri's side are unbeaten in 18 games, while Mauricio Pochettino's side are also in good form too, having won four in a row.
Chelsea can boast a fully fit squad with the entire group having trained on Thursday and Friday ahead of one of their toughest tests of the season.
Emerson Palmieri, N'Golo Kante, Willian and Olivier Giroud were the last to return from international duty on Thursday while injuries picked up by Ethan Ampadu and Mateo Kovacic on international duty appear not to be serious.
Jorginho was also allowed to return early from international duty with Italy, after coming home tired last time around. Sarri confirmed the good news at his Friday press confernece at Cobham Training Ground.
“No big problems. As usual after the national teams, there are some little problems," Sarri said ahead of Spurs. "Some with little injuries, some a little bit tired. Fortunately, we don't have big problems. Kovacic is doing better.
"He had an ankle problem, but he is doing better yesterday in training with the team. And so I think that he will be able to play.”
Neither Chelsea nor Tottenham have any players out with suspensions ahead of Sunday's clash, while there are no players in danger of bans should they pick up yellow cards.
Chelsea Potential Starting Line-Up
Chelsea will put out their strongest side against Spurs at Wembley, with Alvaro Morata earning himself back his starting spot before the international break as he competes with Giroud to start.
Eden Hazard will start on the left wing with Willian and Pedro battling it out for the other spot. Mateo Kovacic and Ross Barkley will continue to try to establish themselves as the third midfielder alongside both Jorginho and Kante.
The defence and goalkeeper is likely to remain unchanged from the 0-0 draw with Everton at Stamford Bridge, as the back five establish themselves as Sarri's first choice for league matches.
Tottenham Team News
Jan Vertonghen is back in training and eases a few selection issues for Pochettino ahead of Chelsea's visit.
Danny Rose and Kieran Trippier are both out with groin injuries. Mousa Dembélé has an ankle issue and Davinson Sanchez is out with a hamstring complaint.
TV channel & kick-off time
The match at Wembley kicks off at 17:30 GMT on Saturday and it will be shown on BT Sport in the UK.
Best Opta Match Facts
Tottenham have won three of their last seven Premier League games against Chelsea, as many as they’d won in their previous 49 top-flight games against the Blues (W3 D18 L28).
Chelsea have won just two of their last 12 away games vs Tottenham in league competition (D5 L5), though they did win this exact fixture 2-1 last season.
Tottenham are looking to win consecutive league games against Chelsea for the first time since August 1987.
This will be the seventh meeting between Tottenham and Chelsea at Wembley Stadium – Chelsea have beaten Spurs four times, more than any club has beaten another at the ground.
Tottenham’s Dele Alli has scored five goals in his last four games against Chelsea in all competitions.