Chelsea face West Ham in another early kick-off on Saturday as they aim to continue their seven-game unbeaten streak in their bid to keep up with Manchester City at the top of the Premier League table.
Antonio Conte's side have had a run of three home games but they don't have to travel far as they face David Moyes's men in this London derby.
West Ham haven't won any of their last eight games which has left them in the relegation zone and they need the points as they welcome the champions of England.
Michy Batshuayi made his return against Atletico Madrid in the Champions League on Tuesday and he is available for the trip to east London. Charly Musonda and Kenedy have also stepped up their recoveries from minor injuries but remain on the fringes of the squad.
The duo played, along with Batshuayi, in the Chelsea development squad's 4-0 win at MK Dons in the Checkatrade Trophy on Wednesday evening.
David Luiz is the only first-team player missing as he has "fluid in his knee" and has been seeking treatment at Cobham Training Centre. He has begun running, which shows sign of progress.
Conte confirmed the team news ahead of West Ham United at a press conference at Cobham Training Centre on Friday. He added that Danny Drinkwater has caught a virus and he will miss the game.
"David Luiz is out. Always for the knee problems. Danny Drinkwater is out, he's sick. This is the third day with a fever," Conte said. "Then we have to check a couple of situations to make the best decision for the game against West Ham United."
Conte also added that several players may be getting tired from the busy fixture schedule.
Alvaro Morata and Antonio Rudiger are one domestic booking away from a suspension, but Chelsea have no players currently suspended. David Luiz and Marcos Alonso are on three bookings.
The cut-off for suspensions after accumulating yellow cards is after 19 league games. Chelsea players need to avoid accumulating five bookings until they play Everton on December 23, thus to avoid a suspension.
Conte was sent to the stands against Swansea and he was fined £8,000 without getting a touchline ban.
POTENTIAL STARTING LINE-UP
Conte will keep rotating his squad with the club having two games per week until January. Pedro, Danny Drinkwater, Willian and Rudiger were among those left out for the Atletico Madrid game.
Marcos Alonso was rested against Atletico so he is expected to return. Batshuayi is closing in on making another start but Conte may not deem him ready to play against West Ham.
Morata and Hazard will likely continue a partnership which is proving to be effective in big games. Chelsea will need to put out a strong line-up as they can't afford to drop points, with leaders Manchester City opening up an 11-point advantage.
However, City face one of their toughest tests of the season yet as they take on Manchester United at Old Trafford on Sunday.
WEST HAM TEAM NEWS
Andy Carroll [knee] and Javier Hernandez [hamstring] are doubts for the match against Chelsea. Cheikhou Kouyate also has a hamstring problem to get over this week, while Mark Noble has a minor hip injury to recover from.
Winston Reid is another who is hoping to be fit after a hamstring injury. Sam Byram and Jose Fonte are both expected to miss out. James Collins is also unlikely to return after suffering a recurrence of his injury while playing for the U23s side.
TV CHANNEL & KICK OFF TIME
The match is on at 12:30 GMT on Saturday and it will be shown live in the UK on SkySports. The highlights will then be shown BBC's Match of the Day.
In the United States (US), West Ham v Chelsea can be watched live and on-demand with fuboTV (7-day free trial).
BEST OPTA MATCH FACTS
West Ham have won just two of their last 22 Premier League games against Chelsea (D4 L16), losing both matches last season 2-1.
Half (4) of the eight Premier League defeats that Chelsea have suffered under Antonio Conte have been in London derby matches – Arsenal, Tottenham and Crystal Palace (twice) during the Italian’s reign.
West Ham United are now eight games without a win in the Premier League (W0 D3 L5), their worst such-run since December 2015. They haven’t gone nine successive games without a win in the top-flight since May 2011.
Eden Hazard has been directly involved in seven goals in his last eight Premier League games against the Hammers (four goals, three assists).
Álvaro Morata has been involved in 13 goals for Chelsea within his first 14 Premier League appearances for the club (nine goals, four assists).