Hosts Celta, meanwhile, come into the match on the back of a defeat, but they will take some confidence from their 2-2 draw against the Blaugrana earlier in the season.
|Game||Celta Vigo vs Barcelona|
|Date||Tuesday, April 17|
|Time||20:00 BST / 15:00 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV, as well as on a web browser.
|US TV channel||Online stream|
|beIN Sports||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Football and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Football||Sky Go|
Squads & Team News
|Goalkeepers||Ter Stegen, Cillessen|
|Defenders||Semedo, Alba, Digne, Vidal, Umtiti, Mina, Vermaelen|
|Midfielders||D. Suarez, Coutinho, Paulinho, Roberto, Gomes|
|Forwards||L. Suarez, Messi, Dembele, Alcacer|
Valverde has signalled his intention to make some changes ahead of the Copa del Rey final, with Gerard Pique, Sergio Busquets and Andres Iniesta missing out through injury.
Ivan Rakitic is also out with a finger injury, but Lucas Digne has been included in the 18-man panel and could play a part.
Potential Barcelona starting XI: Ter Stegen; Semedo, Vermaelen, Umtiti, Alba; Paulinho, Roberto, Coutinho, Dembele; Messi, L. Suarez.
|Position||Celta Vigo players|
|Goalkeepers||Alvarez, Blanco, Sotres, Vieites|
|Defenders||Fontas, Mazan, Castro, S. Gomez, Cabral, Roncaglia, Alende, Pampin|
|Midfielders||Radoja, Lobotka, Jozabed, Wass, Mendez|
|Forwards||M. Gomez, Boye, Aspas, Sisto, Mor, Eckert|
Pablo Hernandez and Hugo Mallo will be unavailable for the match as they serve suspensions, but other than that Juan Carlos Unzue has a full squad to choose from.
Potential Celta Vigo starting XI: Alvarez; Roncaglia, S. Gomez, Castro, Cabral; Wass, Lobotka, Mendez; M. Gomez, Sisto, Aspas.
Betting & Match Odds
Barcelona are favourites to win at odds of 4/6, with Celta Vigo's chances rated 15/4. A draw between the teams is a 16/5 bet.
Barcelona can move 14 points clear at the top of La Liga - temporarily at least - with a win over Celta on Tuesday, which would put them within touching distance of the title.
"We know how tough it will be," Valverde told reporters ahead of the game. "Celta have been playing well at home and they play well against teams in the top half of the table."
Having played Valencia on Saturday and with a cup final to come this weekend, the Blaugrana boss is set to rotate his squad, meaning Lionel Messi and Luis Suarez could be used sparingly.
That doesn't mean they will be taking the game lightly though, as they attempt to continue their record-breaking unbeaten campaign in the Primera Division.