After a flick from Kylian Mbappe, the Uruguay international lashed in to round off a move that started deep in PSG's half and make it 3-0 after 30 minutes and net his 100th in the competition.
At the hour mark, he made it 101 when he sent a powerful shot beyond goalkeeper Mathieu Michel.
The 30-year-old has been in fine form for Unai Emery's side this season, with his latest goal taking his tally to 17 in 16 appearances in all competitions.
Now in his fourth season with PSG, it has taken Cavani just 144 appearances to pass the 100 mark in goals in the French top flight. Josip Skoblar (101 games), Carlos Bianchi (110) Zlatan Ibrahimovic (115) and Delio Onnis (139) are the only players to have reached the milestone in fewer games.
Having starred for Napoli and Palermo before joining PSG, Cavani is only the third player to reach 100 goals in two different leagues this century, after Ibrahimovic and Juventus striker Gonzalo Higuain.
With 35 goals in 36 games last season, Cavani finished the league's top goalscorer and is now joint top of the chart this season with Monaco striker Radamel Falcao.
Beating Angers 5-0 saw the capital club extend their lead at the top of the table to seven points before second-placed Monaco take on Guingamp later in the day.