Ernesto Valverde is without the suspended Sergio Busquets as his side return to league action following the winter break, meaning Ivan Rakitic will be deployed in a deeper midfield role.
Gerard Pique is only a substitute while Samuel Umtiti remains out with an injury, which allows Thomas Vermaelen to continue alongside Javier Mascherano at the heart of the Barca defence.
Valverde's side kick-off six points clear at the top of the Liga table while a victory would see them move 17 points clear of rivals Real Madrid ahead of the Blancos' visit to Celta Vigo on Sunday evening.
Barcelona XI: Ter Stegen; Roberto, Mascherano, Vermaelen, Alba; Paulinho, Rakitic, Iniesta, Dembele, Messi, L.Suarez.
Subs: Cillessen, Semedo, Pique, Digne, D.Suarez, Gomes, Arnaiz.