Departing Arsenal boss Arsene Wenger is expected to ring the changes as he did in last week's 2-1 defeat to Newcastle, with a Europa League semi-final on the horizon against Atletico Madrid.
The Gunners top four hopes are out of sight and the loss at St James' Park all but confirmed that their league season is now a matter of playing for pride above anything else.
Burnley are two points behind the Gunners in the race for sixth spot although Wenger's side will be confident of securing all three points due to their imperious form at Emirates Stadium.
Henrikh Mkhitaryan is running again in training but won't be fit for Sunday's game, while Aaron Ramsey is expected to return to the squad.
Jack Wilshere is out with an ankle injury and goalkeeper David Ospina is available again following his injury lay-off.
Spanish midfielder Santi Cazorla remains a long-term absentee with an Achilles injury.
Arsenal have no suspended players for this game.
Arsenal potential starting line-up
Wenger could rest a number of players with a Europa League semi-final on the horizon.
The likes of Alex Iwobi and Sead Kolasinac could start, while Calum Chambers or Rob Holding are able to fill in for Laurent Koscielny, with the Frenchman carefully managing his chronic Achilles problem.
Pierre-Emerick Aubameyang is expected to return up front and could play alongside Welbeck, who has been in electric form of late.
West Ham team news
West Ham have a five point gap between themselves and the relegation zone but will be hoping for a positive result against an Arsenal side who will have one eye on Thursday's Europa League semi-final against Atletico Madrid.
James Collins could return for West Ham but Winston Reid, Pedro Obiang, Michail Antonio and Sam Byram are all out.
Marko Arnautovic is the club's top scorer with nine goals to his name so far this season.
Best Opta match facts
Arsenal have lost just one of their last 19 Premier League meetings with West Ham (W14 D4), with that defeat coming at the Emirates in August 2015 (0-2).
There has been four hat-tricks scored in Premier League meetings between these sides (Sylvain Wiltord, Thierry Henry, Andy Carroll and Alexis Sanchez) – only Arsenal vs Liverpool (5) has seen more in the competition.
Arsenal have only failed to score in one of their last 31 home league games, in a 0-3 defeat against Manchester City in March.
Mesut Özil has been directly involved in five goals in his last four Premier League games against West Ham (3 goals, 2 assists).
Pierre-Emerick Aubameyang has been involved in eight goals in his opening eight Premier League games for Arsenal (6 goals, 2 assists). Only Andrey Arshavin (6 goals, 3 assists) was involved in more in a player’s first eight for the club in the competition.
Javier Hernandez is yet to score in four Premier League appearances against Arsenal – he’s only faced Norwich (5) more often without finding the net in the competition.
TV channel & kick-off time
The match kicks off at 13:30 BST on Sunday with live television coverage available on Sky Sports in the UK.