Jurgen Klopp's side edged back in front of City at the top of the table on Sunday when Toby Alderweireld's 90th-minute own goal sealed a nervy 2-1 win over Spurs at Anfield.
City can regain a one-point advantage if they win their game in hand against Cardiff City on Wednesday, after which both teams will have six top-flight matches remaining.
"When you see them [score], you say, 'Ah, s**t!' but after five or 10 minutes [you think], 'Nice'," Guardiola chuckled at a pre-match news conference.
"It's a terrible challenge but nobody said it would be easy. Nobody. I knew it, we know it. It's a better challenge.
"It will be amazing what we are going to live against an amazing team, fighting against them."
Manchester City (@ManCity) April 2, 2019
City will once again be a game in arrears after they tackle Brighton and Hove Albion in an FA Cup semi-final at Wembley on Saturday, while Liverpool travel to Southampton in the Premier League a day prior.
Next week brings the first leg of an all-English Champions League quarter-final against Tottenham and Guardiola believes his EFL Cup winners must embrace the experience of chasing an unprecedented quadruple.
"It's amazing to live this opportunity and be there – to beat Cardiff as a main target to be back on the top of the league with six games to go," he said.
"Then after [to] go to Wembley again, to achieve the one final I never played in my life – the oldest trophy ever. And after that the Champions League.
"We passed tough moments in the season to live tough moments and we are fortunate to live it."