Kenyan skipper and Tottenham Hotspur midfielder, Victor Wanyama will miss Tuesday's Champions League return leg match against Borussia Dortmund.
Spurs will visit Signal Induna, but without the influential Kenyan Captain who also missed out on the first leg at Wembley Stadium.
Wanyama is yet to shake off a nagging knee injury he sustained early in August.
The former Southampton and Celtic midfielder has featured only twice for Spurs this season in all competitions; his last appearance for Mauricio Pochettino coming in a 2-1 defeat to champions, Chelsea in the domestic competition.
Pochettino will also have to do without Toby Alderweireld who is also nursing a hamstring injury, though Danny Rose is available for selection.
Spurs have already booked a place into the next stage, but a win over the Germans will see them top the group and land a relatively 'weaker' opponent.