FC Dallas claimed top spot on Saturday but Sporting KC – who have played one more match than their rivals – returned to the summit thanks to Sunday's victory in Kansas City.
In-form Sporting KC and visiting Minnesota traded goals inside the opening 11 minutes at Children's Mercy Park.
Daniel Salloi broke the deadlock in the ninth minute – Sporting KC's Hungarian striker rifling a shot past Bobby Shuttleworth from the edge of the penalty area.
Sporting KC's lead was short-lived as Tim Melia could not keep out Tyrone Mears' long-range effort two minutes later.
Have a go, Tyrone Mears! pic.twitter.com/wzYMDyqEwF— Major League Soccer (@MLS) June 4, 2018
Two goals in three minutes from Wan Kuzain and Cristian Lobato put the home side back in control before half-time – homegrown player Kuzain scoring his first MLS goal in just his second appearance.
Minnesota found themselves reduced to 10 men just past the hour-mark when substitute Luiz Fernando received a second yellow card within 17 minutes of his introduction.
Diego Rubio came off the bench and added a fourth for Sporting KC with nine minutes remaining as the high flyers extended their unbeaten run to five games.