The Blues are comfortably on course to be crowned English champions at the end of the season, but the manager that brought three league titles to Stamford Bridge will undoubtedly be keen to complicate Antonio Conte's path to his first.
|Game||Manchester United vs Chelsea|
|Date||Sunday, April 16, 2017|
|Time||16:00 GMT, 11:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports 1 and by stream via Sky Go.
|UK TV channel||Online stream|
|Sky Sports 1||Sky Go|
In the US, the match will be available to watch live on television on NBCSN and Telemundo (Spanish) and by stream via NBC Sports Live.
|US TV channel||Online stream|
|NBCSN / Telemundo||NBC Sports Live|
SQUADS & TEAM NEWS
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero|
|Defenders||Jones, Rojo, Smalling, Blind, Shaw, Valencia, Darmian, Fosu-Mensah, Bailly, Tuanzebe|
|Midfielders||Mata, Carrick, Young, Herrera, Fellaini, Lingard, Mkhitaryan, Pogba|
|Forwards||Martial, Rooney, Rashford, Ibrahimovic|
United are without Chris Smalling, Phil Jones and Juan Mata, none of whom are likely to play again this season, but David de Gea should be ready to return in goal.
Wayne Rooney and Ashley Young both trained this week and should be fit enough to be involved as substitutes but after a 3-0 win at Sunderland, Mourinho may be tempted to stick with an unchanged outfield 10.
Potential starting XI: De Gea; Darmian, Bailly, Rojo, Shaw; Fellaini, Herrera, Pogba; Lingard, Ibrahimovic, Mkhitaryan.
|Goalkeepers||Begovic, Courtois, Eduardo|
|Defenders||Zouma, Cahill, Terry, Azpilicueta, Aina, Alonso, Luiz, Ake|
|Midfielders||Fabregas, Hazard, Matic, Willian, Loftus-Cheek, Moses, Kante, Chalobah, Kenedy|
|Forwards||Pedro, Costa, Batshuayi, Solanke|
Chelsea have a fully fit squad and, as usual, Conte has only two real selection dilemmas.
They concern whether to partner N'Golo Kante with Nemanja Matic or Cesc Fabregas in midfield and the choice between Pedro and Willian on the right wing. Matic and Pedro started in the 3-1 win at Bournemouth.
Potential starting XI: Courtois; Azpilicueta, Luiz, Cahill; Moses, Kante, Matic, Alonso; Pedro, Costa, Hazard.
BETTING & GAME ODDS
The odds are almost dead even for this match but Manchester United are slight favourites with a best price of 9/5, according to Oddschecker , with Chelsea coming in at 19/10. The draw can be backed at 9/4.
Zlatan Ibrahimovic is 4/1 to score first, with Diego Costa and Eden Hazard following behind him at 5/1 and 7/1 respectively.
This may be the toughest hurdle Chelsea have left to overcome in their pursuit of the Premier League title.
Antonio Conte's men still have to go to Everton, who are in superb form at home, but at Goodison Park they can expect a more open, attacking match than they are likely to find at Old Trafford.
Manchester United have found wins difficult to come by against the top flight's best teams but they are capable of putting up a solid defensive block and ensuring they take at least a point.
Conte will have a decision to make as to whether to stick, by deploying Nemanja Matic alongside N'Golo Kante and taking what United give them, or twist, by fielding Cesc Fabregas instead and attempting to break them down.
The former may be more tempting given Chelsea's advantage over Tottenham in the table and the struggles the Red Devils have had in breaking teams down at home this season.
As far as matches between big hitters in this country go, though, it is more likely to be of interest for its tension - and Mourinho's post-match press conference - than for exciting, fast-paced football.