Premier Soccer League (PSL) clubs have discovered their opponents in the 2018/19 Caf inter-club competitions.
Sundowns, who are the defending PSL champions, will lock horns with Equatorial Guinea's Leones Vegatarianos in the Caf Champions League preliminary rounds.
The winner on aggregate between the two teams will take on either FC Nouadibhou of Mauritania or Libyan club Ahli Benghazi in the play-off rounds.
Last season's PSL runners-up, Pirates, are scheduled to face Light Stars of Seychelles in the Champions League preliminary rounds.
The Buccaneers will then face either Volcan do Moroni of Comoros or Namibian outfit African Stars in the play-off round provided they overcome Light Stars on aggregate.
Amakhosi, who finished third on the PSL standings last season, have been pitted against Zimamoto of Zanzibar in the Caf Confederation Cup preliminary rounds.
The winner between the two teams will face either El Geco of Madagascar or Equatorial Guinea's Deportivo Unidad in the next round.
Meanwhile, Ea Lla Koto, who qualified for the Confederation Cup after winning last season's Nedbank Cup, will take on Rwanda-based outfit Mukura Victory Sports.
If they overcome Sports on aggregate, Luc Eymael's men will then face Sudanese club Al Hilal Obeid in the first round.
The Champions League and Confederation Cup matches will be played over two legs and they are expected to take place on the weekends of 27/28 November and 4/5 December.