The Terriers have endured a dreadful second season in England's top flight and were condemned to the drop by Luka Milivojevic's penalty and a Patrick van Aanholt strike.
It was their fourth loss in a row, having recently failed to pick up points against West Ham as well as Bournemouth and relegation rivals Brighton and Hove Albion.
After earning promotion via the play-offs in 2016-17, Huddersfield sensationally avoided relegation back to the Championship under German coach David Wagner.
However, they struggled to replicate their impressive performances of 2017-18 and Wagner left the club last January with Huddersfield eight points shy of 17th.
They have won just one game under his replacement Jan Siewert, who can now look ahead to the prospect of a Championship campaign next term.
The Terriers' joined Derby County as the only clubs to be relegated from the Premier League before the end of March.
Roy Hodgson's side have moved up to 13th place in the table, eight points clear of the drop.