The teenage forward has been asked to take on a wide role by Garth Southgate, with Tottenham striker Harry Kane leading the line.
The Spurs man will also skipper his country for the first time in the 2018 World Cup qualifier at Hampden Park.
Jake Livermore, meanwhile, has seen his consistency at West Brom recognised with a starting spot, while Joe Hart retains the No.1 jersey between the sticks.
Middlesbrough’s Ben Gibson and Tottenham’s Kieran Tripper have been named among the substitutes but will have their eye on an international debut and first cap.
England team: Hart, Walker, Cahill, Smalling, Bertrand, Dier, Livermore, Lallana, Alli, Rashford, Kane.
Subs: Forster, Trippier, Lingard, Gibson, Stones, Jones, Defoe, Sterling, Oxlade-Chamberlain, Cresswell, Heaton, Butland.
Scotland team: Gordon, Tierney, Berra, Mulgrew, Robertson, Brown, Morrison, Anya, Armstrong, Snodgrass, Griffiths.
Subs: Hamilton, Marshall, R. Martin, Reynolds, Bannan, D. Fletcher, McArthur, Cairney, Fraser, Forrest, C. Martin, Naismith.
England top Group F heading into the contest, having dropped just two points in their five games so far, while Scotland sit fourth.
Gordon Strachan’s side are just two points adrift of a play-off spot and will be seeking revenge for the 3-0 defeat suffered at Wembley in November 2016.erreHerr