Regardless of the reasons behind Wenger's risky call to axe the 28-year-old, former Liverpool, Tottenham and England midfielder Redknapp has identified parallels with other bold but ultimately costly selection gambles.
"Dropping Alexis Sanchez for the trip to Anfield was Arsene Wenger's Ruud Gullit moment," he wrote in the Daily Mail.
"Ruud left [Newcastle favourite] Alan Shearer on the bench for a Tyne-Wear derby in 1999 and it proved to be his downfall — he resigned three days after the 2-1 defeat.
"When things start to go wrong managers can get desperate. [Former Chelsea manager] Andre Villas-Boas left out Ashley Cole, Frank Lampard and Michael Essien for a Champions League first leg against Napoli and in his last full season, [Ex-Liverpool boss] Brendan Rodgers did not pick Steven Gerrard for a trip to the Bernabeu.
"When you make the big call to leave out your best player for such an important match you have to win. Arsenal played into Liverpool's hands on Saturday and Wenger could live to regret his decision."