Dortmund were flying in the early stages of the season as Bayern made an underwhelming start to their title defence.
However, the dismissal of Carlo Ancelotti and return of Jupp Heynckes has produced an upturn in fortunes for the title-holders, which has coincided with a dip in form for Dortmund, who are on a three-match winless run in the league.
Bosz's side were also held to a 1-1 draw against APOEL in midweek to all but end their hopes of reaching the Champions League knockout stages.
With Bayern rejuvenated and Dortmund struggling, Heynckes' side will be fancied by most to take the three points at Signal Iduna Park.
Bosz, though, is in a confident mood, telling a pre-match news conference: "Maybe Bayern come at exactly the right time. We can turn around the feeling with a win.
"We were a bit fortunate in the first couple of weeks, we were not at 100 percent. We don't have that luck right now.
"The results have changed and the opponents see how we play. We now need to do a few things differently."
Bosz has faced criticism in some quarters for sticking to an attacking 4-3-3 formation, but the former Ajax coach insists the pressure is nothing new for him.
He added: "There's always pressure at Dortmund. And when you don't win consecutive matches, there will be even more pressure. And there will be even more when you play Bayern.
"The pressure is there. We need the pressure, too. But you must play better under pressure, and not cramp up.
"You wouldn't believe it if you followed us in the past weeks, but if we win this, we are back at the top of the table.
"I've been through all of this back home. There were many questions [about the system] back then when there were no results and we conceded many goals."