Spurs have already qualified for the knockout stage and will now set their sights on maintaining their unbeaten record and winning the group ahead of Real Madrid.
But Dortmund's chances of reaching the last 16 look slim to none, with their only win since September coming against third-division side Magdeburg in the cup.
|Game||Borussia Dortmund vs Tottenham|
|Date||Tuesday, November 21|
|Time||19:45 GMT / 14:45 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on BT Sport 3 and by stream via the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 3||BT Sport app|
In the US, the match will be available to watch live on television on FS2 and by stream via Fox Sports Go.
|US TV channel||Online stream|
|FS2||Fox Sports Go|
SQUADS & TEAM NEWS
|Position||Borussia Dortmund players|
|Goalkeepers||Weidenfeller, Reimann, Burki|
|Defenders||Zagadou, Subotic, Bartra, Guerreiro, Toljan, Schmelzer, Toprak|
|Midfielders||Sahin, Dahoud, Kagawa, Castro, Weigl|
|Forwards||Yarmolenko, Gotze, Isak, Aubameyang, Philipp, Schurrle|
Dortmund have a lengthy injury list and will be without Christian Pulisic, Marco Reus, Sebastian Rode, Erik Durm, Lukasz Piszczek and Sokratis for this match.
Pierre-Emerick Aubameyang should return, though, after serving a club-imposed suspension for reasons that have not been specified.
Potential starting XI: Burki; Toljan, Bartra, Zagadou, Schmelzer; Gotze, Weigl, Dahoud; Yarmolenko, Aubameyang, Philipp.
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Trippier, Rose, Vertonghen, Sanchez, Foyth, Aurier, Davies, Walker-Peters|
|Midfielders||N'Koudou, Dier, Sissoko, Dembele, Dele, Eriksen, Winks|
|Forwards||Son, Kane, Llorente|
Tottenham are without Victor Wanyama and Toby Alderweireld due to injury.
Erik Lamela has not been registered for this competition and though he is back in full training, he is yet to make a return to competitive action.
Potential starting XI: Lloris; Dier, Sanchez, Vertonghen; Aurier, Sissoko, Winks, Rose; Dele, Llorente, Son.
BETTING & MATCH ODDS
Dortmund are 6/5 favourites to win, according to dabblebet, with Tottenham priced at 11/5 and the draw available at 5/2.
In the Champions League so far this season, though, they have conquered all before them: first Borussia Dortmund and then Real Madrid, taking four points off the reigning European champions.
Mauricio Pochettino must now weigh up whether to do everything in his power to retain that momentum in Dortmund or take the opportunity, with their place in the knockout round already secured, to do a bit of squad rotation.
Harry Kane, Mousa Dembele and Christian Eriksen are among those who could use a rest but their absence from the starting lineup would be felt.
The good news as far as their chances go is that at Signal Iduna Park, it seems to all be falling apart.
After a strong start in the Dortmund dugout, Peter Bosz has endured a horrific past six weeks and has had his authority challenged further by Pierre-Emerick Aubameyang, who publicly questioned a club suspension he was given for an apparent lack of discipline.