Sekotlong leaves the Brazilians without making a single appearance this term.
Last season, which was also his first full season with Sundowns, Sekotlongo featured in 12 matches across all competitions and scored twice.
He will be expected to hit the ground running at Leopards, who are languishing in the bottom half of the table after 18 league matches.
The Thohoyandou-based side didn't have a bright start to the 2018/19 campaign, but they appear to be heading in the right direction under Dylan Kerr, who replaced Joel Masutha towards the end of 2018.
The Mamelodi-born player will also want to use this opportunity to win the heart of Pitso Mosimane, who signed him from Ea Lla Koto when nobody thought he would fit in at Sundowns.
The next five months will be crucial for Sekotlong if he really wants to go back to Chloorkop and prove that he deserves a place in Mosimane's starting line-up, especially with the club likely to make more additions at the start of the new season.
Leopards, on the other hand, will hope to get the best out of Sekotlong, and probably look to hold on to him beyond the expiry of his loan spell in June 2019.