As such, coach Cavin Johnson will be under pressure to mastermind a victory over a wounded Pirates side in Durban.
Meanwhile, Pirates are coming off a disappointing defeat to Highlands Park in the MTN8, which was their third successive defeat across all competitions.
The defeat came after Milutin 'Micho' Sredojevic surprisingly resigned as Bucs head coach on Friday night.
The Serbian tactician has been replaced by caretaker coach Rulani Mokwena, who will be keen to guide the team to a victory over AmaZulu.
|Game||AmaZulu FC vs Orlando Pirates|
|Date||Tuesday, August 20|
TV Channel, Live Stream & How To Watch
In South Africa, the game will be televised live on SuperSport 4.
|SA TV channel||Online stream|
Squads & Team News
AmaZulu could be without Lehlohonolo Majoro, after the former Pirates striker picked up a knock in the team's defeat to Polokwane City.
Michael Morton has also been ruled out of the match since the central midfielder is still recovering from a pre-season injury.
Johnson is expected to look to experienced marksman Bonginkosi Ntuli in the absence of Majoro.
On the other hand, Pirates have suffered a blow ahead of their clash with Usuthu when midfielder Ben Motshwari was ruled out of the game due to an injury.
Injury-prone defender Mthokozisi Dube will also miss the match as he continues to nurse a long-term injury.
Mokwena could bring in midfield maestro Xola Mlambo to fill the gap left by Motshwari in the middle of the park.
AmaZulu will be desperate to end their five-match winless run in the league, including last season's matches.
They have also failed to win their last two home matches in the competition, having drawn with Black Leopards before losing to Wits.
Meanwhile, Pirates saw their 11-match unbeaten run in the league come to an end when they lost to SuperSport away last week.
Their last two away matches were a draw against Cape Town City and a defeat to SuperSport.
In head-to-head stats since 1985, Pirates and AmaZulu have clashed 57 times in league matches.
Bucs have dominated this fixture recording 25 wins compared to 10 for Usuthu and 22 games have been drawn.
Last season, Pirates collected four points from AmaZulu as the two teams drew 1-1 in Durban in the first encounter.
The second clash ended in a 4-1 victory in favour of the Buccaneers in Soweto.