The Gunners are already through to the knockout stages after taking 10 points from their first four Group E matches, and will guarantee first place with a victory at the re-arranged venue.
Having run out 4-2 winners in the reverse home fixture, they are 4/5 (1.80) favourites with bet365 to collect maximum points in Poltava.
Vasyl Sachko's team can keep their chances of progression alive by winning here and hoping Sporting fail to overcome Qarabag in the other fixture, and there are odds of 10/3 (4.33) available on them fulfilling their side of that bargain.
Three of the guests' last four fixtures have resulted in draws, and you can get odds of 13/5 (3.60) on them being forced to settle for another stalemate in this one.
Laurent Koscielny remains unfit for first team action despite featuring for the U23s on Monday night, while Alexandre Lacazette and Stephan Lichtsteiner are doubts. Danny Welbeck, Konstantinos Mavropanos and Nacho Monreal all sidelined.
Aleksandre Kobakhidze, Denis Vasin and Dmitry Kravchenko are all unavailable through injury for the hosts.
Poor home form
Although trips to Eastern Europe are typically described as the archetypal difficult away tie in continental competition, this clash should not hold any fear for Unai Emery's in-form outfit.
The Zeleno-Bili have taken zero points from their opening two group matches on home turf, and lost five of the last six fixtures in front of their own fans in all competitions.
Unbeaten in 17 games in all competitions and looking to wrap up top spot in the group, those 4/5 (1.80) odds certainly look generous on Arsenal proving their class by coming out on top against an unimpressive Vorskla.
Odds correct at the time of writing. Please gamble responsibly.