Having lost out 3-2 when the sides met in February's exciting EFL Cup final at Wembley, the Saints are available at 9/5 (2.80) with Betfair Sportsbook to get their own back by coming out on top here.
Jose Mourinho made no secret of his prioritisation of the upcoming Europa League final following Sunday's defeat against Tottenham, but his side are on offer at 9/5 (2.80) to bounce straight back from that result with a first league victory in five matches.
None of the last six encounters between these dudes have resulted in draws, but you can get odds of 23/10 (3.30) on them cancelling each other out in this one.
Boasting five goals, a stirring comeback, and a late winner, the clash at Wembley offered all the entertainment one could hope from a cup final. However, those expecting a repeat performance in this game look likely to be very disappointed on current form, with both teams finding goals hard to come by in recent weeks.
Responsible for two of the goals at Wembley and both strikes in a 2-0 victory at Old Trafford in August’s reverse fixture, Zlatan Ibrahimovic’s absence through injury has significantly hampered the Red Devils’ threat in attack.
With just six goals to their name in seven matches since their star striker was ruled out for the season, the visitors may struggle to break down a defence that has kept clean sheets in two of their last four games.
However, Claude Puel’s men have proved even less efficient up front recently, scoring just five times in their last seven and drawing blanks in each of the last two at home.
With this in mind, even odds (2.00) seem generous on no more than one side finding the net for the fourth time in five league encounters between the sides, as well as both Southampton and United’s sixth league game in eight respectively.