After drawing 0-0 away to Lyon last month, there was a hint of uncertainty about Barca's position heading into the return leg, particularly when Lucas Tousart pulled one back on Wednesday to make it 2-1.
At that stage, another goal would have sent Lyon through on away goals, but Barca – or more specifically Messi – stepped things up in the final 12 minutes.
The Argentina star scored one to add to his first-half penalty, before setting up Pique and Ousmane Dembele to wrap up what ultimately proved to be a comfortable win.
Goals.— FC Barcelona (@FCBarcelona) March 13, 2019
Man. Of. The. Match. pic.twitter.com/Pj9DVkDPSm
Barca head into the last eight as one of the favourites, with Messi's presence giving them an extra level few clubs can reach.
"The big stars add up to a lot," said Pique. "Behind them, they have to have great teams to help them, because it is historically proven that a player cannot win big competitions [alone].
"But, obviously, having players like Messi in the team makes you have another level.
"When you have doubts, as has been the case [against Lyon], they appear and give you the peace of mind necessary to progress."
Messi's latest double takes his overall record for the season across all competitions to 36 goals in 35 appearances for Barca.
He will be expected to retain his place in Ernesto Valverde's starting XI this weekend for the trip to Real Betis in La Liga, as the Blaugrana aim to preserve their seven-point lead at the top of the table.