Rafael Benitez's team have taken just one point from their opening four fixtures in the league, while the Magpies also crashed out of the League Cup after suffering a dismal defeat against Championship side, Nottingham Forest.
Arsenal were beaten in both of their first two Premier League matches but Unai Emery's side have claimed back-to-back wins in their most recent fixtures, against West Ham United and Cardiff City respectively.
Pierre-Emerick Aubameyang and Alexandre Lacazette linked up for the first time this season in the victory against Cardiff and should both start again, meaning Henrikh Mkhitaryan is likely to miss out again.
Joselu had to settle for a place on the substitutes' bench for Newcastle's visit to Manchester City, but as the Magpies' leading marksman thus far this term, the Spanish striker is pushing for inclusion this weekend.
There have been at least three goals scored in four of Newcastle's five matches thus far this term, while Arsenal's four fixtures have produced no fewer than 16 goals.
Newcastle have found the net in each of their four defeats this season and that trend that could continue on Tyneside in Saturday afternoon.
The Gunners boast plenty of power in the attacking third, but Emery's men are vulnerable and have yet to keep a clean sheet this term.
The 5/2 (3.50) quote, then, for both teams to score and Arsenal to win could put punters on a path to profit ahead of Saturday's showdown at St James' Park.
Odds correct at time of writing. Please gamble responsibly.