There is an Accra derby on the cards as the Ghana Football Association Normalisation Committee Special Competition enters matchday five on Sunday.
Twenty-time domestic champions Hearts of Oak are away to local rivals Liberty Professionals at Dansoman's Carl Reindorf Park in Zone A.
The fifth-placed Phobians, who returned to winning ways in the last matchday after two successive defeats, will hope to register their third victory of the campaign against the Scientific Soccer Lads, who sit second on the table.
Elsewhere in the zone, leaders Wafa face a tricky trip to wounded Dreams FC, who lost 2-1 to Inter Allies on Thursday.
The Eleven-Is-To-One, meanwhile, will play away to third-placed Karela United. Allies have won one of their four games played so far.
In Cape Coast, bottom-positioned Ebusua Dwarfs, having lost all four matches played thus far, are eyeing their first point when they host Elmina Sharks, who have drawn three of four games played.
In Zone A, Asante Kotoko will hope to consolidate their lead on the table with another three points when they face Bechem United away. With one win, one draw and one defeat in three games played thus far, the Hunters occupy the fifth position.
The fixture between Ashanti Gold and Medeama is undoubtedly the topliner of the matchday in the zone. The two teams are separated by just one point and one position on the table, the Yellow and Mauves sitting as the superior side.
In Techiman, bottom-placed Eleven Wonders are aiming for their first victory of the campaign in their home tie against Berekum Chelsea, who are similarly without a win in the championship.
The match between Stallions FC (formerly Wa All Stars) and second-positioned Aduana Stars has been postponed.