Last week's first leg saw Jose Mourinho's side put in an impressive performance to return from northern Spain with a 1-0 victory.
In truth, the manager may feel a little frustrated that his side did not put the tie to bed given the fact they had a number of chances to score more than the solitary goal they managed. United nevertheless are in a strong position, although Celta have shown before this season they are capable of achieving big wins away from home.
In the previous round, Eduardo Berizzo's men overturned a 1-0 first leg defeat with a 2-0 win in Ukraine against Shakthar Donetsk, while January saw them become the first Spanish side - other than Barcelona and Atletico Madrid - to win at the Bernabeu in six years with a 2-1 Copa del Rey success.
Winning the Europa League is almost certainly United's best route into next season's Champions League, and the side's relative disappointment domestically this term can be attributed in large part to their lack of goals.
Manchester United are only the ninth highest scorers in the Premier League which is an extraordinary statistic, and with their top scorer out for the rest of the season, they seem devoid of a killer instinct in the final third.
Celta, for their part, are an attacking, exciting side although the feeling was that the froze a little in the first leg given the magnitude of their first ever European semi-final. Under 2.5 goals is offered at 4/5 (1.80) and has paid out in 14 of the Red Devil's last 16 matches in all competitions as well as proving the correct selection in each of their last seven home games.
Celta looked overwhelmed in the first leg, and we have seen little from them in recent weeks to make us think they are capable of heading to Old Trafford and score twice.