With Wednesday's 2-1 loss to Lyon, Man City became the first ever English club to lose four consecutive matches in Champions League play.
The latest loss in Man City's streak came in Wednesday's opener, as the Citizens conceded goals to Maxwel Cornet and Nabil Fekir before the stroke of half-time.
A Bernardo Silva finish in the second half wasn't enough for City despite the introductions of Leroy Sane and Sergio Aguero
The first loss of Man City's streak came in February's round of 16 clash with Basel, as Pep Guardiola's side followed a 4-0 first leg win with a 2-1 loss to advance to the quarter-finals.
Once there, City ran into Liverpool, who cruised to a 3-0 win at Anfield before the eventual Premier League champions fell 2-1 at the Etihad to seal an embarrassing exit.
There were few signs of weakness from Man City entering Wednesday's match with a 1-1 draw at Wolves proving the only early blemish on the club's initial five-game run through Premier League play.
Widely seen as one of the favorites to win the Champions League this season, Man CIty were left without a point on matchday 1 thanks to a standout effort from the opposition.
4 - Manchester City are the first English team to lose four consecutive Champions League matches in the competition's history. Surprising. pic.twitter.com/of1x71hxC3— OptaJoe (@OptaJoe) September 19, 2018
The French side hadn't been particularly impressive heading into Wednesday's match, as the club currently sit seventh in Ligue 1 with two wins and two losses from five matches.
Lyon's win was on Wednesday was the first ever by a French club at City in European play, signaling a major upset that surely shakes up Group F play while demonstrating that Man City still have some lessons to learn when it comes to playing on the continent.
1 - Lyon have become the first French 🇫🇷 team to win at Manchester City in European competition. Upset. pic.twitter.com/jxIA1k0tUY— OptaJean ⭐⭐ (@OptaJean) September 19, 2018
In fact, six of the last eight times City have conceded twice in the first half of a match at home the games have been in the Champions League.
6 - Six of the last eight instances of Manchester City conceding twice in the first half of a match at the Etihad have been in the Champions League. Theme. pic.twitter.com/itnIPpZnZE— OptaJoe (@OptaJoe) September 19, 2018
Man City's next Champions League match will come against Hoffenheim on October 2 following Premier League matches against Cardiff and Brighton as well as a League Cup clash with Oxford.