The Reds go into the weekend two points clear of Manchester City at the top of the table, having playing one game more.
Having lost just one of their last 24 home games against this opposition in the league, they are 11/20 (1.55) favourites with bet365 to give their title bid a boost with a high profile victory here.
Mauricio Pochettino's men are looking anxiously over their shoulders after picking up just one point from the last available 12, but can be backed at 5/1 (6.00) to bolster their place in the top four by coming out on top.
Two of the last three league meetings between this pair at this ground have resulted in draws, and you can get odds of 3/1 (4.00) on them cancelling each other out once again.
Trent Alexander-Arnold, Xherdan Shaqiri and Naby Keita will all face late fitness tests, although Joe Gomez and Alex Oxlade-Chamberlain are still short of match fitness despite returning to training following long-term injuries.
Eric Dier and Serge Aurier are ruled out after sustaining injuries on international duty, while Kyle Walker-Peters and Harry Winks are both doubtful.
Last season's respective fixture was certainly a memorable affair, with Mohamed Salah looking to have won the game in injury time - only for Harry Kane to make it 2-2 with a 95th-minute penalty.
There was more late action in the reverse encounter at Wembley back in September, when Erik Lamela's 93rd-minute goal made for a nervy end in a 2-1 victory for Jurgen Klopp's team.
Fans are advised against leaving early on Sunday, particularly as Spurs have seen goals scored in the final 10 minutes of seven of their last nine matches.
With four of Liverpool's last five fixtures producing goals in the last 10 minutes, odds of 5/6 (1.83) seem like solid value on either them or Tottenham scoring after the 76th minute in this one.7
All odds correc t at time of publish. Please gamble responsibly.