Remarkably, the Reds are unbeaten in the last 17 renewals of this rivalry and, yet to taste defeat in the Premier League this season, Jurgen Klopp's charges will be confident of heaping yet more misery upon their Merseyside rivals.
Liverpool are warm favourites to take all three points on Sunday, with SportPesa offering just 4/11 (1.36) that the Reds make home advantage count.
The Toffees have not won at Anfield since turn of the century and Marco Silva's side will be desperate to put that particular statistic to bed this weekend.
SportPesa go 15/2 (8.50) that it is the blue half of Merseyside that is celebrating on Sunday, while the same firm go 15/4 (4.75) that the match ends in a draw - five of the last eight league matches between the teams has ended level.
Adam Lallana and Alex Oxlade-Chamberlain remain sidelined for the hosts, while captain Jordan Henderson is suspended after being sent off against Watford last weekend. Klopp may be tempted to freshen things up after an energy-sapping Champions League clash on Wednesday night.
Everton have a fully fit squad from which to choose; Richarlison is expected to continue in attack, while Icelandic playmaker Gylfi Sigurdsson will be tasked with pulling the strings for the visitors.
Away struggles hampering Everton?
Silva's side are inside the top six but that is down to Everton's impressive home form as away from Goodison Park, they have won just one of six league games so far this season, conceding at least two goals in four of those fixtures.
Liverpool have scored 14 Premier League goals at Anfield this season and have conceded just one.
Everton, though, carry a considerable threat in attack, for the Toffees have scored in 13 of their 15 fixtures so far this season.
Silva's side are capable of exposing any tired legs in the home ranks and the 21/20 (2.05) quote from SportPesa for both teams to find the net - and for more than two goals to be scored - could provide punters with a path to profit ahead of Sunday's crunch clash.