Both sides have started the season with six wins and a draw from seven games, and this clash will surely go some way to finding out whether the Reds can assert their claim for the trophy.
Having beaten the Citizens on three separate occasions last season, Jurgen Klopp’s men are 7/5 (2.40) favourites with Betway to take the points here and go clear of their title rivals.
However, City have won 11 of their last 13 away matches in all competitions and can be backed at 17/10 (2.70) to emerge victorious at Anfield for the first time since 2003.
The draw has occurred just twice in the last 13 meetings between the sides but is available at 11/4 (3.75).
Kevin De Bruyne has returned to training but this game comes too soon for the Belgian, whilst Ilkay Gundogan limped off against Hoffenheim on Tuesday and is doubtful. Benjamin Mendy could return and Fabian Delph is out.
Naby Keita was taken off in the first half of Wednesday's Champions League loss at Napoli but should be fit for at least a place on the bench. Alex Oxlade-Chamberlain and Adam Lallana remain on the treatment table.
No two sides scored more goals than Liverpool and City last season, with the pair scoring a stunning 190 times in the Premier League between them.
This term has been no different as the sides have racked up 36 goals already, and although both defences have combined to concede on just six occasions, this clash almost always has plenty of goals.
Tip and Predictions
Despite how impressive both defences have been this season, value surely lies in goals and over 1.5 first half goals appeals at 13/10 (2.30).
This would have paid out in three of last term’s four meetings between the pair and also in four of City’s seven Premier League games this time around.