Cristiano Ronaldo had given Madrid the lead midway through the second period with a coolly taken penalty - his 21st goal in just 13 appearances against Sevilla.
The build-up to this fixture saw the clubs involved in a spat surrounding Sevilla fans' treatment of Sergio Ramos during the Copa clash, and the home fans will have taken delight in the Madrid captain heading past his own goalkeeper to level matters.
But worse was to come for the leaders as, in stoppage time, our Head and Shoulders Super Player Stevan Jovetic marked his maiden league appearance for Sevilla with the winner - curling a shot from just outside the box that Keylor Navas could only parry into the bottom-right corner.
Navas failed to keep out Jovetic's effort, Sevilla fans and players ecstatic at the final whistle as a shell-shocked Madrid were forced to contemplate their long undefeated run coming to a close.
The victory - Sevilla's eighth at home from nine league outings this season - lifts them above Barcelona and into second, a point behind Madrid who have a game in hand.