The two sides are set to battle it out for three points at Wembley Stadium in what will be their penultimate Group B fixture.
With Barcelona already with one of the two qualification tickets from the group to the next round, the outcome of Wednesday’s fixture will prove crucial.
“We are here to play our own game and to bring back the win,” Asamoah said at a pre-match conference on Tuesday.
“I know that it won’t be easy. However, with a winning mentality, we know that we can get a good result.
“I’ve already played here and I know what it’s like taking on a team like Tottenham.
“We’ve grown a lot as a team since the first game, which for many players was their first in the Champions League.
“We now have more confidence in our abilities. Personally, I have also grown in confidence after playing more often.”
Inter currently sit second on the table, three points below leaders Barcelona but three marks above third-placed Tottenham.
Dutch side PS Eindhoven, meanwhile, sit bottom of the table.
Asamoah, who joined the Nerazzurri in the summer, is expected to maintain his place in coach Luciano Spalletti’s XI for Wednesday’s game, having started each of the four previous matches.