Odion Ighalo and Alex Iwobi will both start from the sidelines as Gernot Rohr look to Kelechi Iheanacho and Ahmed Musa in a different looking Nigeria setup against Iceland at the Volgograd Arena.
Completing the changes is defender Kenneth Omeruo who replaces right-back Abdullahi Shehu, joining the duo of Leon Balogun and William Troost-Ekong in a three-man defence as the German tactician reverts to a 3-5-2 formation.
Musa and Iheanacho will spearhead what promises to be a pacy, dynamic attack, with Victor Moses hoping to replicate his performance as a right wing-back at Chelsea in Nigeria's eye-catching kits. Brian Idowu provides the needed width on the opposite wing.
However, midfielders Wilfred Ndidi, Oghenekaro Etebo and captain John Obi Mikel retain their spot and youngster Francis Uzoho continues between the sticks.
After their uninspiring opening encounter against Croatia, where they lost 2-0, there were backlashes as regards the team's setup and some player's performances. And Rohr, obviously, has tweaked his plan.
The Group D bottom-placed side had their hopes up again after Zlatko Dalic's men continued their impressive form with a 3-0 bashing of a Lionel Messi-led Argentina on Thursday evening.
Iceland, missing star winger Johann Berg Gudmundsson, lined up in a 4-4-2 for this clash.
However, Rohr's wards would hope to ride on the momentum Croatia's victory has left them with as they take to the field against the Vikings in Volgograd.