Only two players based in Europe will be eligible for Mexico's friendly Tuesday against the United States, with Hirving Lozano, Erick Gutierrez and Guillermo Ochoa not traveling to Nashville.
All three players took part in Mexico's 4-1 loss Friday to Uruguay but will fly back to Europe from Houston rather than make the trip to Tennessee for the second match of the FIFA window.
Ochoa was the starting goalkeeper for the World Cup and played all 90 minutes of the loss to Uruguay, conceding a pair of set-piece goals to a phenomenal Luis Suarez.
Gutierrez played an hour of the contest, though PSV directors may have been nervous while watching. The Dutch champions signed Ryan Thomas to fill their need in the midfield during the offseason but saw Thomas go down to a knee injury during his first week in training.
Gutierrez was signed as a replacement after PSV's progression in the Champions League freed up more cash for the club but is yet to make his debut. He'll join Lozano in Eindhoven where his countryman has become one of the club's most important players since arriving in summer 2017. "Chucky" played 72 minutes against Uruguay, winning a penalty.
Mexico interim manager Ricardo "Tuca" Ferretti had hinted that he would make changes to his roster after the Uruguay game, though he said the team would still look to utilize more or less the same tactics as it did against the South Americans.
"I'm going to talk and plan with my players to put together a tactical plan. Players in the starting lineup for Tuesday, yes, you're going to see a lot of changes," Ferretti said. "You're going to see a lot of changes because I want to see all the elements brought in for these two international matches. I'm also going to count on the others if I need to make a change or there's some other situation."
The United States made a similar change, with center back John Brooks heading back to Wolfsburg after the Americans' 2-0 loss to Brazil. However, a dozen players who represent European clubs still remain in the U.S. squad.