While Spurs' title hopes have long since evaporated, the North London side still have plenty to play for after being sucked into a battle for a top four spot with Arsenal, Manchester United and Chelsea.
The Reds must be wary of Mauricio Pochettino's team, who are the second best away team in the division behind Jurgen Klopp's hosts.
Kane has been involved in four goals (scoring three and one assist) in his last four matches at Anfield and will be primed to give Liverpool's swashbuckling centre-half Virgil van Dijk a tough encounter.
Dele Alli's recent return from injury is a significant boost for Tottenham, who should be able to field a full-strength attack against the Reds stingy defence.
While Liverpool have still only lost one league game this season, their recent performances in the Premier League haven't been all that impressive.
Sadio Mane has been Klopp's in-form man of late, scoring nine goals in his last nine Premier League matches, but more is needed from two of Liverpool's star attackers.
Roberto Firmino's brace against Burnley are his only league strikes in his past seven games, while Mohamed Salah only has one goal in eight Premier League contests.
Manchester City have a highly winnable game against cellar dwellers Fulham, meaning Liverpool can't afford to slip up and give Pep Guardiola's team clear sight of the title.