The Three Lions are in high spirits after following up last summer's World Cup semi-final by reaching the finals of the UEFA Nations League.
While the latter achievement has already guaranteed them a place in the play-offs, they are 2/7 (1.29) favourites with bet365 to get their pursuit of automatic qualification off to a winning start.
Having failed to qualify for the World Cup, Jaroslav Silhavy's men are priced at 10/1 (11.00) to give their chances of reaching the Euros a major boost by pulling off a shock win.
The sides shared a 2-2 draw when they met at this ground in a friendly in 2008, and you can get odds of 4/1 (5.00) on this one also finishing up all square.
Luke Shaw, John Stones, Trent Alexander-Arnold, Ruben Loftus-Cheek and Fabian Delph have all withdrawn from the squad. Marcus Rashford has also pulled out while Jordan Henderson is doubtful due to an ankle injury.
Tomas Vaclik has been ruled out with a muscle injury, meaning Rennes goalkeeper Tomas Koubek is likely to start.
Defensive Czech Republic
Appointed after Karel Jarolim was dismissed following a 5-1 friendly defeat against Russia, Silhavy has tightened things up at the back in his four matches in charge.
However, while they have managed to concede just twice in those games, they have also scored only four times at the other end of the pitch.
This doesn't bode well for a match against Gareth Southgate's side, which has lost just one out of 15 home games under his command - keeping 10 clean sheets.
All things considered, odds of 8/11 (1.73) look like solid value on England winning to nil against a defensive Czech Republic on Friday.
Odds correct at the time of writing. Please gamble responsibly.