The 19-year-old defender has emerged as one of the most sought-after talents in European football.
Goal has revealed that Juventus are preparing to step up their interest in De Ligt, while Barcelona president Josep Maria Bartomeu has claimed to be aware of what the Netherlands international’s next move will be.
De Boer concedes that the summer transfer window is likely to deliver a change of scenery as Ajax, who have already sanctioned a €75 million (£65m/$85m) switch to Camp Nou for Frenkie de Jong, brace themselves for interest to be shown in a number of their most prized assets.
“What is so great about this team, they are a proper Ajax team, they all have balls,” De Boer told The Telegraph.
“When you look at someone like De Ligt, he is already attracting a lot of interest and his departure is pretty much unstoppable. He is such a talent, he can play in any team, in any system, he will go on to have a brilliant career. He is not the only one.
“For me, there are three or four who could be sold because the amount of money involved, it makes it so hard for Ajax to resist. It is sad this has to happen, but it is football I suppose.”
With De Jong already destined to depart and De Ligt seemingly heading the same way, it remains to be seen how many others will make their way to the exits at the Johan Cruyff Arena this summer.
Nicolas Tagliafico is another to be sparking transfer talk, amid links to Arsenal and Barcelona, while Hakim Ziyech is said to be attracting admiring glances from Bundesliga heavyweights Bayern Munich and Borussia Dortmund.