The trip to Russia comes at a testing time for Lopetegui, with his side looking for some consistency after a slightly uneven start to the season.
Madrid head to Moscow with a number of injury concerns. Isco and Marcelo are unavailable while Gareth Bale went off on Saturday night at half time against Atletico and is unlikely to play on Tuesday.
CSKA will be missing Uruguyan forward Abel Hernandez, who remains injured.
Unlike Real Madrid's impressive start, CSKA needed an injury time penalty to salvage a 2-2 draw at Viktora Plzen in their opening Champions League game.
This does not bode well for the hosts as Madrid have won nine of their last 11 away games in the competition, scoring in 13 successive matches on the road.
Los Blancos, therefore, should be able to find a way through against a CSKA side that has kept one clean in their last 35 Champions League matches.
Tips and predictions
After a long trip and a difficult week we should not expect Real Madrid to run riot in Moscow, but the price of 29/20 (2.45) for an away win and under 3.5 goals in the game looks to be an excellent option.Real Madrid to win and under 3.5 goals at 29/20 (2.45) for a 1pt stake with SportPesa