Although hardly neighbours, the pair have developed a rivalry over the course of their numerous promotion battles in the last few decades.
Having lost just one of their last nine home matches in the league, Chris Hughton’s men are priced at 9/5 (2.80) to send the fans home happy with a precious win here.
This fixture resulted in a 0-0 draw last campaign, and you can get odds of 2/1 (3.00) on the teams cancelling each other out once again.
Bruno will face a late fitness test after limping off late on in Saturday's win at Huddersfield, while Alireza Jahanbakhsh remains injured and Dale Stephens serves the final match of his three-game suspension.
Connor Wickham and Scott Dann could both be back in contention following long injury lay-offs, although Christian Benteke is still short of fitness.
While Benteke and Wickham’s absence is certainly an issue for a team that has struggled for cutting edge this season, Roy Hodgson’s men will still back themselves to cause problems for the hosts after finding the net in five of their seven away matches so far.
The Seagulls can certainly be got at after going four fixtures without a clean sheet, although pose a significant threat at the other end of the pitch given they have scored in 10 of their last 11.
All in all, odds of 21/20 (2.05) look generous on an exciting derby match producing goals at both ends for the third meeting in a row between Brighton and Palace.