Lucien Favre's side have been in fantastic form on home soil in this competition this term, scoring seven goals without reply and the fervent home supporters will be expecting more of the same against Brugge.
Brugge had been beaten in seven successive Champions League ties away from home, before a stunning 4-0 win against Thierry Henry's Monaco earlier this month.
As a consequence, the Belgian champions have an outside chance of making the last 16, but they must win here and William Hill offer 8/1 (9.0) that Ivan Leko's charges deliver against Dortmund.
Dortmund have no fresh worries ahead of this Champions League clash, with in-form German international, Marco Reus, ready to spearhead the attack for Favre's men.
Leko could field the same side as he did in Monaco, for Brugge have no fresh injury concerns to contend with. Both Arnaut Danjuma and Jelle Vossen remain out.
Dortmund have found the net in each of their last 10 Champions League ties on home soil and have scored 20 goals in their last five home wins in this competition.
The German side have struck at least three times in all but one of their last six Champions League home victories and, with a place in the last 16 within reach, Favre's men will be fired up ahead of Wednesday's tie.
The 6/5 (2.20) quote, then, from William Hill for the hosts to score more than two goals could well represent good value for punters ahead of this Champions League clash.