Having lost the first leg 2-1 at San Siro Stadium, Mauricio Pochettino’s men will aim to avoid a repeat and boost their chances of securing a place in the round of 16.
The Lilywhites have been impressive lately winning their previous five games including a 3-1 victory over rivals Chelsea on Saturday and are backed by Bet365 to come out on top at the price of (1.75).
A share of spoils at the end of 90 minutes of action is available at the odds of (4.00) with the same betting firm.
Luciano Spalletti’s men have not been at their best in their away games in the Champions League, winning only once in their previous four fixtures outside the San Siro and have been tagged as underdogs for this encounter at (4.80).
Harry Kane has scored four goals in four outings in the tournament and boasts of 11 goals across all competitions this season which makes the odds of (1.75) a good value for the England captain to score anytime according to Bet365.
Odds correct at the time of writing. Please gamble responsibly.