The Blancos have conquered Europe in each of the last three seasons, and four of the last five.
They are, however, about to embark on a first continental adventure in nine years without a five-time Ballon d’Or winner within their ranks.
The Greece international told Marca ahead of a Champions League opener against Julen Lopetegui’s side on Wednesday: “He [Ronaldo] is a champion, but Madrid will always be Madrid.
“Now they play more as a team. Now players like Gareth Bale, who were always behind Ronaldo, like everyone is, are appearing.
“That was logical and now you will see the talent of all the players and the team. The whole team played for him and now it will be stronger, I'm sure.”
Despite acknowledging the strength of Real, Manolas insists Roma head to Santiago Bernabeu with no fear.
“Never. We are not scared of anyone,” he added.
“Respect yes, but fear no. They have an amazing team, a great spine, great up front, at the back... but fear, no.”
While Roma are preparing to face a Blancos side without Ronaldo, they are set to meet the 33-year-old on a domestic stage this season.
He said: “Ronaldo in recent times has been at an incredible level, the best in the world.
“He has scored so many goals, won a load of Champions Leagues, a European Championship with Portugal, a load of good games. He has been at an incredible level and it's normal to speak about him.”